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pentobarbital will lessen the level or impact of buprenorphine, prolonged-acting injection by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Clients who transfer to buprenorphine extended-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers must be monitored to make sure bupren